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Dr. Furdui is Professor of Internal Medicine with joint appointments in the Department of Cancer Biology and Department of Biochemistry at Wake Forest School of Medicine and Affiliate Faculty in the Department of Chemistry, Wake Forest University. She serves as Co-Director of the Center for Redox Biology and Medicine and of the NIGMS-funded T32 Training Program in Redox Biology and Medicine with Dr. Poole. Her laboratory applies chemical, molecular and systems biology approaches to investigate redox-regulated processes with significance to human health. Dr. Furdui is principal investigator or co-investigator on numerous research grants from National Institutes of Health and Department of Army. She is an inventor on 2 issued patents and one provisional patent.
KEY AREAS OF EXPERTISE: Redox Chemical Tools and Analytical Methods; Omics and Systems Biology; Redox Biochemistry; Redox Mechanisms of Disease; Cancer Therapies and Mechanisms of Resistance
Chen, XF, Lee, JY, Wu, HZ, Tsang, AW, Furdui, CM 2019, Mass Spectrometry in Advancement of Redox Precision Medicine, Adv Exp Med Biol. 1140:327-358.
Poole, LB, Wani, R, Qian, J, Yin, L, Bechtold, E, King, SB, Tsang, AW, Furdui, CM (2011) Isoform-specific regulation of Akt by PDGF-induced reactive oxygen species. Proc Natl Acad Sci U S A. 108(26):10550-5.
Poole, LB, et al. 2022. [18F]Fluoro-DCP, a first generation PET radiotracer for monitoring protein sulfenylation in vivo. Redox Biol. 49:102218.
Dr. King is a Professor of Chemistry with joint appointments in Molecular Medicine and Cancer Biology at Wake Forest University. The overall theme of his research has been the application of organic chemistry toward understanding redox-mediated biological processes. Projects have focused on the generation of reactive nitrogen species (RNS) from clinically used drugs, such as hydroxyurea and nitroaromatic antibiotics, the development of new methods for nitroxyl (HNO) generation and organosulfur chemistry related to redox biology, especially the preparation and evaluation of chemical probes for protein sulfenylation and detection in biological systems. These projects have produced more than 120 publications and 9 issued patents.
KEY AREAS OF EXPERTISE: Synthetic Organic Chemistry; Organic Compound Purification and Structural Identification; Organic Reaction Mechanisms; Redox and Co-factor Biochemistry; Nitrogen Oxide Chemistry; Chemical Probes for Protein Sulfenylation.
Negrellos, A., Rice, A. M., Dos Santos, P. C., & King, S. B. (2023, December 15). Sulfinamide Formation from the Reaction of Bacillithiol and Nitroxyl. ACS Chemical Biology, 18(12), 2524–2534.
DuMond, JF & King, SB (2011). The chemistry of nitroxyl-releasing compounds. Antioxid Redox Signal, 14(9), 1637-48.
Miao, Z & King, SB (2016). Recent advances in the chemical biology of nitroxyl (HNO) detection and generation. Nitric Oxide, 57(1), 1-14.
Dr. Poole is Professor of Biochemistry at Wake Forest School of Medicine, served as Director of the Center for Structural Biology for more than a decade, and is currently Co-Director (and Co-PI of a related T32-supported training program) of the Center for Redox Biology and Medicine. With Drs. Bruce King and Cristina Furdui she develops chemical reagents and approaches to evaluate protein redox control that impact human health (targeting oxidation products). She is an inventor on 6 issued and several pending patents, and was named a Fellow of the Society for Redox Biology and Medicine in 2017. Dr. Poole holds a Distinguished Investigatorship (R35) from the National Institute of General Medical Sciences (NIGMS), and has had multiple grants supporting these innovative technologies from the National Cancer Institute.
KEY AREAS OF EXPERTISE: Protein Thiol Chemistry; Chemical Probes for Protein Sulfenylation; Enzyme Kinetics; Peroxiredoxins in Health and Biology; Redox Regulation of Signaling Proteins.
Among her >150 scientific papers (of which 2 have been cited more than 1000 times, and 36 more than 100 times) are several in particular to guide those new to the field of redox biochemistry in terms of biochemical principles and methodological recommendations:
Poole, FRBM 2015, The basics: Poole, L. B. (2015) The basics of thiols and cysteines in redox biology and chemistry, Free Radic Biol Med 80, 148-157
Poole, Furdui and King, Essays in Biochem, 2020: Poole, L. B., Furdui, C. M., and King, S. B. (2020) Introduction to approaches and tools for the evaluation of protein cysteine oxidation, Essays Biochem 64, 1-17.
Qiwei Hu, Rama D Yammani, Heather Brown-Harding, David R Soto-Pantoja, Leslie B Poole, John C Lukesh 3rd (2022) Mitigation of doxorubicin-induced cardiotoxicity with an H2O2-Activated, H2S-Donating hybrid prodrug, Redox Biol. 53: 102338